10–16% of the NCLEX-RN

Safety & Infection Control NCLEX practice questions

Standard and transmission-based precautions, error prevention, restraints, hazardous materials, emergency response, and safe use of equipment. Renamed "Safety and Infection Prevention and Control" in the 2026 test plan.

10–16%of scored items on the 2026 test plan
108Safety & Infection Control questions in the Aegis bank
6free samples below
Question 1 Multiple choice medium

A nurse is caring for a client with active TB. Which PPE should the nurse wear when entering the room?

  1. A.Surgical mask and gloves
  2. B.N95 respirator
  3. C.Sterile gown and gloves
  4. D.Standard precautions only
Show answer and rationale

Correct answer: B · TB airborne precautions

TB requires airborne precautions: N95 respirator (or PAPR), negative-pressure room, door closed.

Question 2 Multiple choice medium

A client has an AV fistula in the left arm for hemodialysis. Which is correct?

  1. A.Use the fistula arm for blood draws and BP
  2. B.Avoid BP, blood draws, and IV access in fistula arm; assess thrill and bruit daily
  3. C.Apply tight pressure to the fistula
  4. D.Allow client to lie on the fistula arm
Show answer and rationale

Correct answer: B · AV fistula care

AV fistula care: NO BP, blood draws, IV, or constrictive clothing on fistula arm. Daily assessment for thrill (palpate) and bruit (auscultate) — absent = clotted, notify provider.

Question 3 Multiple choice medium

A nurse is caring for a client on droplet precautions. Which PPE must be worn?

  1. A.Gloves only
  2. B.Surgical mask + standard precautions; N95 not required
  3. C.N95 respirator
  4. D.Gown and gloves only
Show answer and rationale

Correct answer: B · Droplet precautions PPE

Droplet precautions: surgical mask within 3-6 ft. Examples: influenza, pertussis, meningococcus, mumps. Airborne (TB, measles, varicella) requires N95.

Question 4 Multiple choice medium

A client has clostridium difficile infection. Which hand hygiene method is required after caring for this client?

  1. A.Alcohol-based hand rub only
  2. B.Soap and water — alcohol does NOT kill C. difficile spores
  3. C.Hand sanitizer
  4. D.Wiping with paper towel
Show answer and rationale

Correct answer: B · C. diff hand hygiene

C. diff spores resist alcohol-based rubs. Use soap and water with mechanical action. Contact precautions, dedicated equipment, environmental cleaning with bleach.

Question 5 Select 4 hard

A nurse is providing care for a client with COVID-19 infection in a hospital. Which precautions are appropriate? Select 4.

  1. A.Place on droplet and contact precautions; airborne for aerosol-generating procedures
  2. B.Wear N95 respirator for aerosol-generating procedures (intubation, suctioning, BiPAP)
  3. C.Use eye protection (face shield/goggles) and gown and gloves
  4. D.Use a private room or cohort with COVID+ patients
  5. E.Allow visitors freely without PPE
  6. F.Standard precautions are sufficient
Show answer and rationale

Correct answer: A, B, C, D · COVID-19 precautions

COVID-19: droplet + contact + eye protection routine, airborne (N95) for AGP. Private room or cohort. PPE for visitors. Vaccinate staff.

Question 6 Select 4 hard

A 4-year-old presents with fever 39.5°C, drooling, tripod position, muffled voice, and refuses to lie down. Which actions are appropriate? Select 4.

  1. A.Maintain a calm environment and avoid agitating the child
  2. B.Do not attempt to visualize the throat with a tongue blade
  3. C.Prepare for possible intubation with anesthesia/ENT present
  4. D.Notify provider for emergency airway support
  5. E.Place the child supine for examination
  6. F.Allow the child to be alone to rest
Show answer and rationale

Correct answer: A, B, C, D · Epiglottitis emergency

Suspected epiglottitis = airway emergency. Keep child calm with caregiver, do NOT examine throat (could cause complete obstruction), prepare for intubation in OR with anesthesia/ENT, IV antibiotics. Supine worsens obstruction.

What Safety & Infection Control tests

  • Transmission-based precautions
  • Fall and injury prevention
  • Restraint safety
  • Medication error prevention
  • Emergency response plans
  • Handling hazardous materials

How to study it

Drill this category in the app until your accuracy holds above 70%, then move it into mixed practice. Aegis tracks Safety & Infection Control separately in your coverage map and will surface it as "today's best move" when it is the weakest link in your readiness score.

Back to all categories · See the 4-week study plan

Safety & Infection Control FAQ

What percentage of the NCLEX-RN is Safety and Infection Prevention and Control?

Safety and Infection Prevention and Control makes up 10–16% of scored items on the 2026 NCSBN NCLEX-RN Test Plan, effective April 1, 2026.

What topics does Safety & Infection Control cover?

Standard and transmission-based precautions, error prevention, restraints, hazardous materials, emergency response, and safe use of equipment. Renamed "Safety and Infection Prevention and Control" in the 2026 test plan. Key content areas include transmission-based precautions, fall and injury prevention, restraint safety, medication error prevention, and more.

How many Safety & Infection Control questions are in Aegis?

108 standalone questions, plus related sub-questions inside the 100 NGN case studies. The free tier gives you 25 questions a day across any category.

Other categories

Practice 108 Safety & Infection Control questions in the app.

25 questions a day, 3 NGN case studies, and a full mock exam are free. No account, no sign-up.

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